About ESTRING® (estradiol vaginal ring)

Estring | Once for 90 days

Full Prescribing Information | Patient Information | Important Safety Information

What exactly is ESTRING?

ESTRING^® (estradiol vaginal ring) is an off-white, soft, flexible ring with a core that contains 2 mg of estradiol (an estrogen hormone). This 2-inch ring releases a steady, low dose of estrogen each day to help relieve the symptoms of vaginal atrophy, and it’s inserted once every 90 days as prescribed by your doctor.

After 90 days, there won’t be enough estradiol in the ring to maintain its full effect in relieving your vaginal or urinary symptoms. ESTRING should be removed at that time and replaced with a new ESTRING if your doctor determines that you need to continue your therapy.

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INDICATION

ESTRING^® (estradiol vaginal ring) is used after menopause to treat moderate to severe vaginal itching, burning and dryness, painful intercourse, urinary urgency, and painful urination due to urogenital atrophy.

Important Safety Information

Estrogens increase the risk of cancer of the uterus. It is important that you report any unusual vaginal bleeding to your doctor right away. Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your risk of heart attack, stroke, breast cancer, or blood clots. Using estrogens with or without progestins may increase your risk of dementia, based on a study of women aged 65 years or older. Estrogens should only be used for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment with ESTRING.

ESTRING should be removed after 90 days of continued use.

Do not use ESTRING if you have unusual vaginal bleeding, have or have had cancer of the breast or uterus, had a stroke or heart attack, have or have had blood clots or liver problems, are allergic to any of its ingredients, or think you may be pregnant.

The most frequently reported side effects are headaches, increased vaginal secretions, vaginal discomfort, abdominal pain, and genital itching.

Call your healthcare provider right away if you have any of the following warning signs: breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pain in your legs, or changes in vision.

Carefully follow instructions for use. If you have difficulty removing ESTRING, contact your healthcare provider right away.

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