ESTRING (estradiol vaginal ring) is an estrogen indicated for the treatment of moderate to severe urogenital symptoms due to postmenopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

ESTRING may help relieve some of the postmenopausal symptoms such as:

• Vaginal dryness, burning, or itching
• Painful sexual intercourse
• Sudden urges to urinate (use the bathroom)
• Painful or difficult urination

You should not use ESTRING if you:

• Have unusual vaginal bleeding
• Currently have or have had certain cancers
  Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use ESTRING
• Had a stroke or heart attack in the past year
• Currently have or have had blood clots
• Currently have or have had liver problems
• Are allergic to any of the ingredients in ESTRING
  See the list of ingredients in ESTRING
• Think you may be pregnant

Tell your doctor or healthcare provider:

• If you are breastfeeding
• About all of your medical problems. You may have to be checked more carefully if you have asthma (wheezing), epilepsy (seizures), migraine, endometriosis, lupus, or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood
• About all the medicines you take
• If you are going to have surgery and/or will be on bed rest

Once placed in the upper vagina, ESTRING releases estradiol. Estradiol is a natural plant-based form of estrogen, which your body makes less of than it used to make. ESTRING will release the medicine in a steady, low dose for a 90-day treatment period.

After 90 days, there will not be enough treatment in the ring to provide you with relief. ESTRING should be taken out at this time. You should talk to your healthcare provider to see if you should continue treatment with ESTRING.

ESTRING contains the estrogen estradiol. Therefore, ESTRING should be used only as long as needed. You and your healthcare provider should talk every 90 days to see if you still need to continue treatment with ESTRING.

ESTRING can be inserted by you or your healthcare provider.
For step-by-step instructions on inserting and removing ESTRING, click here.

It will take between 2 and 3 weeks to restore the tissue of the vagina and urinary tract to a healthier condition. But every woman is different.

If your symptoms persist for more than a few weeks after using ESTRING, call your healthcare provider.

When inserted properly in the upper vagina, most women should not feel the ring once it is in place.

Most women and their partners should not experience discomfort with ESTRING in place when having sex, so it is not necessary to remove the ring before sex. Some women may choose to remove it prior to sex. However, be sure to put it back in soon afterwards.

If you take ESTRING out, be sure to rinse it in lukewarm water before you put it back in.

If you feel it, ESTRING may be too low in your vagina. To push it in further, simply use your finger.

No. ESTRING cannot be pushed too far up in the vagina or get lost. ESTRING will not go farther than the end of the vagina. The cervix (the narrow, lower end of the uterus) blocks ESTRING from going up any further.

If you have any concerns or additional questions about inserting ESTRING, contact your doctor or healthcare professional.

You should follow all of the instructions for ESTRING carefully. Also, talk with your healthcare provider often about whether you should continue to use ESTRING.

• See your healthcare provider right away if you get vaginal bleeding while using ESTRING
• If you have fever, nausea, vomiting, diarrhea, muscle pain, dizziness, faintness, or a sunburn-like rash on your face and body, remove ESTRING and contact your healthcare provider right away
• You should also have a breast exam and mammogram (breast X-ray) every year unless your healthcare provider tells you something else. If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram, you may need to have breast examinations more often
• If you have high blood pressure, high cholesterol (fat in the blood), diabetes, are overweight, or smoke, you may have higher chances for getting heart disease. Ask your healthcare provider for ways to lower your chances for getting heart disease