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Ingredients in ESTRING

ESTRING® (estradiol vaginal ring) is a slightly opaque ring with a whitish core containing a drug reservoir of 2 mg estradiol (an estrogen hormone). Estradiol, silicone polymers and barium sulfate are combined to form the ring.

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Safety Information

Important safety information you should know about ESTRING

You should discuss the potential benefits and risks of ESTRING® (estradiol vaginal ring) with your healthcare provider. ESTRING contains the hormone estrogen, which may increase the risk of cancer of the uterus. Therefore, it is important that you report any unusual vaginal bleeding to your healthcare provider right away.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your risk of heart attack, stroke, breast cancer, blood clots, and dementia.

Who should not use ESTRING?

Menopause is the time in a woman’s life when her menstrual cycle ends. It begins when it has been one year after her last period.

You should not use ESTRING if you:

  • Have unusual vaginal bleeding
  • Currently have or have had certain cancers
    Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use ESTRING
  • Had a stroke or heart attack in the past year
  • Currently have or have had blood clots
  • Currently have or have had liver problems
  • Are allergic to any of the ingredients in ESTRING
    See the list of ingredients in ESTRING
  • Think you may be pregnant

Tell your doctor or healthcare provider:

  • If you are breastfeeding
    The hormone in ESTRING can pass into your breast milk
  • About all of your medical problems
    Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), migraine, endometriosis, lupus, or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood. You may have to be checked more carefully if you have asthma (wheezing), epilepsy (seizures), migraine, endometriosis, lupus, or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood
  • About all the medicines you take such as prescription and nonprescription medicines, vitamins, and herbal supplements.
  • If you are going to have surgery or will be on bed rest
    You may need to stop using estrogens

A possible side effect of ESTRING

A few cases of toxic shock syndrome (TSS) have been reported in women using vaginal rings. Toxic shock syndrome is a rare but serious illness caused by a bacterial infection. If you have fever, nausea, vomiting, diarrhea, muscle pain, dizziness, faintness, or a sunburn-like rash on face and body, remove ESTRING and contact your healthcare provider.

The most common side effect of ESTRING

The most frequently reported side effect with ESTRING use is increased vaginal secretions. Many of these vaginal secretions are like those that normally occur prior to menopause, and indicate that ESTRING is working. Vaginal secretions that are associated with a bad odor, vaginal itching, or other signs of vaginal infection are NOT normal and may indicate a risk or a cause for concern.

The most common reasons for discontinuing ESTRING treatment, due to an adverse event, were vaginal discomfort and gastrointestinal symptoms.

This is some of the most important information to know about ESTRING. For more information, please click here to read the patient prescribing information.

Next Section: Talking With Your Doctor

Indication

ESTRING® (estradiol vaginal ring) is an estrogen indicated for treatment of moderate to severe urogenital symptoms due to postmenopausal atrophy of the vagina (such as dryness, burning, pruritus, and dysparuenia) and/or the lower urinary tract (urinary urgency and dysuria).

Important Safety Information

Estrogens increase the risk of cancer of the uterus. It is important that you report any unusual vaginal bleeding to your healthcare provider right away.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.

Using estrogens with or without progestins may increase your risk of heart attack, stroke, breast cancer, blood clots, and dementia. Using estrogens with or without progestins may increase your risk of dementia, based on a study of women age 65 years or older.

You and your healthcare provider should talk regularly about whether you still need treatment with ESTRING® (estradiol vaginal ring).

ESTRING should be removed after 90 days of continued use.

Do not use ESTRING if you think you may be pregnant. Estrogens should not be used during pregnancy. ESTRING is not a contraceptive.

Do not use ESTRING if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots or liver problems; or if you are allergic to any of its ingredients.

The most frequently reported side effect of ESTRING is increased vaginal secretions. Other side effects may include vaginal discomfort, abdominal pain, or genital itching.

If you have fever, nausea, vomiting, diarrhea, muscle pain, dizziness, faintness, or a sunburn-like rash on your face and body, remove ESTRING and contact your healthcare provider right away.

While using ESTRING, carefully follow the instructions for use and talk to your healthcare provider regularly about whether you still need to use ESTRING.

If you have vaginal bleeding or difficulty removing ESTRING, contact your healthcare provider right away.

Important Safety Information

Estrogens increase the risk of cancer of the uterus. It is important that you report any unusual vaginal bleeding to your healthcare provider right away. Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your risk of heart attack, stroke, breast cancer, blood clots, and dementia. Using estrogens with or without progestins may increase your risk of dementia, based on a study of women age 65 years or older. You and your healthcare provider should talk regularly about whether you still need treatment with ESTRING® (estradiol vaginal ring).

ESTRING (estradiol vaginal ring) is an estrogen indicated for treatment of moderate to severe urogenital symptoms due to postmenopausal atrophy of the vagina (such as dryness, burning, pruritus, and dysparuenia) and/or the lower urinary tract (urinary urgency and dysuria).

ESTRING should be removed after 90 days of continued use.

Do not use ESTRING if you think you may be pregnant. Estrogens should not be used during pregnancy. ESTRING is not a contraceptive.

Do not use ESTRING if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots or liver problems; or if you are allergic to any of its ingredients.

The most frequently reported side effect of ESTRING is increased vaginal secretions. Other side effects may include vaginal discomfort, abdominal pain, or genital itching.

If you have fever, nausea, vomiting, diarrhea, muscle pain, dizziness, faintness, or a sunburn-like rash on your face and body, remove ESTRING and contact your healthcare provider right away.

While using ESTRING, carefully follow the instructions for use and talk to your healthcare provider regularly about whether you still need to use ESTRING.

If you have vaginal bleeding or difficulty removing ESTRING, contact your healthcare provider right away.