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Ingredients in ESTRING

ESTRING® (estradiol vaginal ring) is a slightly opaque ring with a whitish core containing a drug reservoir of 2 mg estradiol (an estrogen hormone). Estradiol, silicone polymers and barium sulfate are combined to form the ring.

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Are you ready 4 relief?

ESTRING® (estradiol vaginal ring) is an estrogen indicated for the treatment of moderate to severe urogenital symptoms due to postmenopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Ask your healthcare provider about ESTRING.

How can ESTRING help?

ESTRING and conjugated estrogens vaginal cream had no difference in efficacy for the treatment of vaginal symptoms in two 12 week controlled trials for postmenopausal women.

ESTRING may help give you relief from some vaginal and urinary symptoms after menopause.

4 comfort In a US study, 95% of patients rated the comfort of ESTRING as "excellent" or "very good" compared with 65% of patients receiving conjugated estrogens vaginal cream.

4 ease of use In the same study, 95% of patients judged ESTRING to be “easy” or “very easy” to use compared with 88% of patients receiving a vaginal estrogen cream.

4 three months One ring for 90 day use. The need to continue treatment should be assessed by your doctor.

4 her relief ESTRING is a local estrogen therapy designed to relieve moderate to severe itching, burning and dryness in and around the vagina after menopause. It provides relief of local symptoms of menopause only.

Talk to your healthcare provider to find out if ESTRING is right for you.

* These savings are good when presented with a valid, signed prescription for ESTRING. Coupon is limited to up to $20 on 1 prescription or the amount of your co-pay, whichever is less. This coupon will only be accepted at participating pharmacies. This coupon is not health insurance. There are no membership fees. For any questions, please call Customer Service at 1-800-631-1181. Pfizer Inc. 235 East 42nd Street, New York, NY 10017 www.pfizer.com


Next Section: Menopause and You

Indication

ESTRING® (estradiol vaginal ring) is an estrogen indicated for treatment of moderate to severe urogenital symptoms due to postmenopausal atrophy of the vagina (such as dryness, burning, pruritus, and dysparuenia) and/or the lower urinary tract (urinary urgency and dysuria).

Important Safety Information

Estrogens increase the risk of cancer of the uterus. It is important that you report any unusual vaginal bleeding to your healthcare provider right away.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.

Using estrogens with or without progestins may increase your risk of heart attack, stroke, breast cancer, blood clots, and dementia. Using estrogens with or without progestins may increase your risk of dementia, based on a study of women age 65 years or older.

You and your healthcare provider should talk regularly about whether you still need treatment with ESTRING® (estradiol vaginal ring).

ESTRING should be removed after 90 days of continued use.

Do not use ESTRING if you think you may be pregnant. Estrogens should not be used during pregnancy. ESTRING is not a contraceptive.

Do not use ESTRING if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the past year; currently have or have had blood clots or liver problems; or if you are allergic to any of its ingredients.

The most frequently reported side effect of ESTRING is increased vaginal secretions. Other side effects may include vaginal discomfort, abdominal pain, or genital itching.

If you have fever, nausea, vomiting, diarrhea, muscle pain, dizziness, faintness, or a sunburn-like rash on your face and body, remove ESTRING and contact your healthcare provider right away.

While using ESTRING, carefully follow the instructions for use and talk to your healthcare provider regularly about whether you still need to use ESTRING.

If you have vaginal bleeding or difficulty removing ESTRING, contact your healthcare provider right away.