Vaginal Atrophy Relief

Making the Right Choice matters

Making the Right Choice matters

One option for women is Estring. Here’s why:

Estring is a soft, flexible ring that provides a low, continuous dose of estrogen for 90 days to help relieve moderate-to-severe symptoms of postmenopausal vaginal atrophy.

How it works

How it works:


Explore the ring below to learn more about it:

The Estring core contains the medicine: 2 mg of estradiol (an estrogen hormone).

Estring is soft and flexible.

It’s a cream-free treatment option that doesn’t have to be applied daily: a single ring lasts for 90 days.

Estring gradually releases estrogen for 90 days at the site of pain, helping restore vaginal tissue to a healthier condition. In a U.S. 12-week trial, Estring demonstrated equal efficacy to a conjugated estrogens vaginal cream.

95% of women in the trial who tried Estring rated product comfort as excellent or very good*

95% of women in the trial who tried Estring rated it very easy or easy to use once inserted*

*A 12-week, open-label, randomized, parallel, multicenter study in the United States compared the efficacy, safety, and patient acceptance of Estring with a conjugated vaginal estrogens cream in the treatment of 192 postmenopausal women with urogenital symptoms due to estrogen deficiency.

Keep in mind that estrogen therapies such as Estring should be used only as long as needed. You and your doctor should talk regularly about whether you still need treatment with Estring.

Patient Testimonials

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You might have more questions.

We have answers.

See below for some Frequently Asked Questions about Estring.

What is Estring?

Estring is a slightly opaque, soft, flexible vaginal ring with a center that contains 2 mg of estradiol (an estrogen hormone). It releases estradiol into the vagina in a consistent, stable manner for 90 days. Estring is indicated for the treatment of moderate-to-severe symptoms of vulvar and vaginal atrophy due to menopause.

What are some side effects of Estring?

Less serious but common side effects include:

  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach/abdominal cramps, bloating
  • Nausea and vomiting
  • Fluid retention
  • Vaginal yeast infection

Less common but serious side effects include:

  • Heart attack
  • Stroke
  • Blood clots
  • Dementia
  • Breast cancer
  • Cancer of the lining of the uterus (womb)
  • Cancer of the ovary
  • High blood pressure
  • High blood sugar
  • Gallbladder disease
  • Liver problems
  • Changes in your thyroid hormone levels
  • Enlargement of benign tumors of the uterus (“fibroids”)
What are some risks of Estring?

Do not start using Estring if you:

  • Have unusual vaginal bleeding
    • Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause
  • Currently have or had certain cancers
    • Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use Estring
  • Had a stroke or heart attack
  • Currently have or had blood clots
  • Currently have or had liver problems
  • Have been diagnosed with a bleeding disorder
  • Are allergic to Estring or any of its ingredients (Please see the list of ingredients in the Patient and Prescribing Information)
  • Think you may be pregnant
    • Estring is not for pregnant women. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not use Estring if the test is positive and talk to your healthcare provider
How do I store Estring?

Estring can be kept anywhere convenient, like your bathroom cabinet. It should be stored at room temperature between 59°F and 77°F (15°C and 25°C).

How long should I use Estring?

Estrogens should be used at the lowest dose possible, only for as long as needed. Estring should be removed after 90 days of continued use. You and your doctor should talk regularly about whether you still need treatment with Estring.

Will I or my partner feel Estring?

Most women and their partners do not experience any discomfort with Estring in place, including during sex, so you don’t have to remove the ring before sex. However, if you choose to remove it, be sure to put it back in soon afterward.

If you take Estring out, rinse it in lukewarm (not hot) water before you put it back in. If you can feel it, Estring may be too low in your vagina. To push it in farther, simply use your finger. For more information on how to insert and remove Estring, watch our instructional video.

Can Estring be inserted too far?

No. Estring cannot be pushed too far up in the vagina or get lost. Estring will not go past the end of the vagina. The cervix (the narrow, lower end of the uterus) blocks Estring from going up any further. If you have any concerns or additional questions about inserting Estring, contact your doctor.

What if my Estring falls out?

No need to worry. It’s rare, but has been reported in cases of intense coughing or straining. If this happens, just rinse the ring with lukewarm water and reinsert it. Do not wash the ring in hot water.

How do I dispose of Estring?

Simply dispose of Estring in your regular wastebasket. Do not flush Estring down the toilet.

What are other things to tell my doctor?

Call your healthcare provider if you get any of the following warning signs:

  • New breast lumps
  • Unusual vaginal bleeding
  • Changes in vision or speech
  • Sudden new severe headaches
  • Severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue
  • Memory loss or confusion

Before starting Estring, tell your doctor or healthcare professional:

  • If you have unusual vaginal bleeding. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause
  • If you have other medical conditions. Your healthcare professional may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood
  • If you are going to have any surgery or will be on bed rest. Your healthcare provider will let you know if you need to stop using Estring
  • If you are breastfeeding. The hormone in Estring can pass into your breast milk
  • About all the medicines you take, such as prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how Estring works. Estring may also affect how your other medicines work